Agglomeration of silica nanoparticles impacts significantly their uptake by cells
JRC scientists demonstrated the effect of silica nanoparticle agglomeration on the level and mechanism of their uptake by cells, i.e. agglomerated particles accumulated more in cells than non-agglomerated ones and presented a modified mechanism of cellular internalisation.
Silica nanoparticles (NPs) are increasingly present in variety of consumer products including cosmetics and food supplements.
They are in development for diverse medical applications such as drug delivery systems, tissue engineering and biosensors.
Silica nanoparticles can enter human cells via different mechanisms and induce intended (or not) biological effects