Modified viruses deliver death to antibiotic-resistant bacteria : Nature News & Comment

AMI Images/SPL

Phages (green) attack a bacterium (orange). Researchers are hoping to use engineered versions of these viruses to fight antibiotic resistance.

Genetically modified viruses that cause bacteria to kill themselves could be the next step in combating antibiotic-resistant infections.

Several companies have engineered such viruses, called bacteriophages, to use the CRISPR gene-editing system to kill specific bacteria, according to a presentation at the CRISPR 2017 conference in Big Sky, Montana, last week. These companies could begin clinical trials of therapies as soon as next year.

Initial tests have saved mice from antibiotic-resistant infections that would otherwise have killed them, said Rodolphe Barrangou, chief scientific officer of Locus Biosciences in Research Triangle Park, North Carolina, at the conference

http://www.nature.com/news/modified-viruses-deliver-death-to-antibiotic-resistant-bacteria-1.22173

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